✦ LIBER ✦

NMR Backbone Assignment of a Protein Kinase Catalytic Domain by a Combination of Several Approaches: Application to the Catalytic Subunit of cAMP-Dependent Protein Kinase

✍ Scribed by Thomas Langer; Martin Vogtherr; Bettina Elshorst; Marco Betz; Ulrich Schieborr; Krishna Saxena; Harald Schwalbe

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 465 KB
Volume: 5
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200400129

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

E230Q mutation of the catalytic subunit

E230Q mutation of the catalytic subunit of cAMP-dependent protein kinase affects local structure and the binding of peptide inhibitor

✍ Man-Un Ung; Benzhuo Lu; J. A. McCammon 📂 Article 📅 2006 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 484 KB 👁 1 views

## Abstract The active site of the mammalian cAMP‐dependent protein kinase catalytic subunit (C‐subunit) has a cluster of nonconserved acidic residues—Glu127, Glu170, Glu203, Glu230, and Asp241—that are crucial for substrate recognition and binding. Studies have shown that the Glu230 to Gln mutant