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NMR assignments and conformational studies of two diastereomeric oxidation products of 2′-deoxycytidine

✍ Scribed by E. Ämmälahti; M. Bardet; J. Cadet; D. Molko

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
245 KB
Volume
36
Category
Article
ISSN
0749-1581

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✦ Synopsis

Structural assignment and conformational features of two diastereomeric oxidation products of 2@deoxycytidine, the 5S* and 5R* diastereomers of N1-(2-deoxy-b-D-erythro-pentofuranosyl)-5-hydroxyhydantoin were achieved by combining NMR studies and restrained molecular dynamics. Interproton distances were measured from NOESY and ROESY experiments. The absolute conÐguration of these two compounds was unambiguously determined and their conformation properties in solution were also studied.

1998 John Wiley & Sons, ( Ltd.

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