๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

NMR analysis of structure and function of snake neurotoxins

โœ Scribed by Tatsuo Miyazawa; Toshiya Endo; Fuyuhiko Inagaki; Kyozo Hayashi; Nobuo Tamiya

Publisher
Wiley (John Wiley & Sons)
Year
1983
Tongue
English
Weight
374 KB
Volume
22
Category
Article
ISSN
0006-3525

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โœฆ Synopsis

The 270-MHz proton-nmr spectra of short neurotoxins (erabutoxins from Laticauda semifasciata and cobrotoxin from Naja naja atra) and long neurotoxins (toxin B from Naja naja and a-bungarotoxin from Bungarus multicinctus) have been analyzed. The conformation of erabutoxin b in solution is largely consistent with the x-ray crystal analysis, although the environment of His-7 in solution is definitely different from that in the crystal. The pH-dependent transition has been found for toxin B, indicating that the conformation in neutral solution is different from that in the crystal as grown from acidic solution. The deuterium-exchange rates of the amide protons for the four neurotoxins have been measured. The order of structural rigidity is the same as the order of the irreversibility of neuromuscular block by neurotoxins.

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