✦ LIBER ✦
NMR analysis of fluorinated corticosteroids related to fluocinonide: Detection of long-range 1H–19F couplings using the heteronuclear equivalent of the COSY experiment
✍ Scribed by Donald W. Hughes; Alex D. Bain; Valerie J. Robinson
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 795 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Abstract
The analysis of the ^1^H and ^19^F NMR spectra of the corticosteroid fluocinonide and five related steroids is reported. The 500 MHz ^1^H NMR spectra revealed several previously undetected long‐range ^1^H–^19^F coupling constants. These couplings were assigned by the application of the heteronuclear equivalent of the COSY pulse sequence. The fluorine substituent effects and long‐range heteronuclear couplings were examined in relation to structures derived from molecular mechanics (MMX) calculations.