NMR analyses of conformation of ribosyl adenosine 5′,5″-bis(phosphate) in aqueous solution
✍ Scribed by Fuyuhiko Inagaki; Tatsuo Miyazawa; Masanao Miwa; Hazime Saito; Takashi Sugimura
- Book ID
- 119406597
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 284 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0006-291X
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## Synopsis The molecular conformation of adenosine-5'-monophosphate (5'-AMP) in D20 (pH 8.1) has been investigated by the method of "DESERT" proposed earlier by Akasaka e t al. [J. Magn. Reson. 18,328 (1975)]. The reciprocal sixth-power-averaged distances F, ?3 between H(8) of the adenine ring an
## Abstract CD and nmr studies show that the conformational equilibrium of N(P)‐alkylated adenosine 5′‐phosphorodiamidates **2**–**4** and, to a much lesser extent, adenosine 5′‐phosphorodiamidate **1** differ at two parts from that of adenosine 5′‐phosphate in water. The glycosidic bond conformati
## Abstract A computer program developed for the simulation of proton spin‐lattice relaxation times (__T__~1~) was applied to the conformational analysis of adenosine 5′‐phosphate (5′‐AMP) in neutral D~2~O solution. The __T__~1~ values of all the non‐exchangeable protons of 5′‐AMP were calculated f