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NMDA-sensitive l-[3H]glutamate binding in cerebral cortex of El mice

✍ Scribed by Katsuhiko Oguro; Masatoshi Ito; Hideo Tsuda; Kozo Mutoh; Hideyuki Shiraishi; Yukiyoshi Shirasaka; Haruki Mikawa

Book ID
103932172
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
393 KB
Volume
6
Category
Article
ISSN
0920-1211

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✦ Synopsis

NMDA-sensitive L-[3H]glutamate binding was examined in the brains of El mice, a genetic animal model of epilepsy, and in ddY mice. In whole brain, Scatchard analysis showed that both stimulated and unstimulated El mice had significantly lower Bmax values for binding than did ddY mice. In regional studies, the binding of NMDA-sensitive L-[3H]glutamate was significantly less in the cerebral cortex of both stimulated and unstimulated El mice than in that of ddY mice. These data suggest that NMDA receptors may be involved in the genetic susceptibility of El mice to seizures.

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✍ A. B. Young; G. W. Dauth; Z. Hollingsworth; J. B. Penney; K. Kaatz; S. Gilman πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 1003 KB

Excitatory amino acids (EAA) such as glutamate and aspartate are probably the neurotransmitters of a majority of mammalian neurons. Only a few previous studies have been concerned with the distribution of the subtypes of EAA receptor binding in the primate brain. We examined NMDA-and quisqualate-sen