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NMDA receptor blockade inhibits glutamate-induced kindling of the rat amygdala

✍ Scribed by M.J. Croucher; H.F. Bradford

Book ID
115801012
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
313 KB
Volume
506
Category
Article
ISSN
0006-8993

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A competitive (NBQX) and a non-competitive (GYKI 52466) AMPA antagonist, and a competitive NMDA antagonist (D-CPPene) were tested against the development of kindling and against fully kindled seizures in amygdala-kindled rats. GYKI 52466, 10 mg/kg given i.p. 5 min prior to electrical stimulation in