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NMDA receptor antagonists inhibit kindling epileptogenesis and seizure expression in developing rats

✍ Scribed by Barbara L. Trommer; Joseph F. Pasternak

Book ID
119101631
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
481 KB
Volume
53
Category
Article
ISSN
0165-3806

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A competitive (NBQX) and a non-competitive (GYKI 52466) AMPA antagonist, and a competitive NMDA antagonist (D-CPPene) were tested against the development of kindling and against fully kindled seizures in amygdala-kindled rats. GYKI 52466, 10 mg/kg given i.p. 5 min prior to electrical stimulation in