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NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in mice

✍ Scribed by Hack-Seang Kim; In-Sook Park; Woo-Kyu Park

Book ID: 117175989
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 545 KB
Volume: 63
Category: Article
ISSN: 0024-3205
DOI: 10.1016/s0024-3205(98)00519-0

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The effects of aniracetam on the head-twitch response (HTR) induced by 5-hydroxy-L-tryptophan (5-HTP) and (±)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI) as a model of hallucination were examined in rodents. 1) Aniracetam produced a dose-related (30, 100, and 300 mg/kg po) redu