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NMDA Preconditioning Protects against Seizures and Hippocampal Neurotoxicity Induced by Quinolinic Acid in Mice

✍ Scribed by Carina R. Boeck; Marcelo Ganzella; Amilcar Lottermann; Deusa Vendite


Book ID
110726850
Publisher
Wiley (Blackwell Publishing)
Year
2004
Tongue
English
Weight
172 KB
Volume
45
Category
Article
ISSN
0013-9580

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In this investigation, 40 mg/kg of the excitatory neurotoxin kainic acid (KA) was subcutaneously administered to CD2-F1 mice. In this mouse strain morphological damage induced by KA in the hippocampus was markedly concentrated in the CA3 pyramidal neurons. Neuronal injury was accompanied by several