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NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3β-induced apoptosis

✍ Scribed by Agata Habas; Giorgi Kharebava; Erzsebet Szatmari; Michal Hetman


Book ID
111179284
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
394 KB
Volume
96
Category
Article
ISSN
0022-3042

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re