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NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway

✍ Scribed by Mi-Young Lee; Woo-Jeong Jeong; Jong-Won Oh; Kang-Yell Choi


Book ID
116335021
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
394 KB
Volume
275
Category
Article
ISSN
0304-3835

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## Abstract Epidermal growth factor (EGF) and Ras mitogenic signal transduction pathways are frequently activated in breast carcinoma and inhibit mammary differentiation and apoptosis. HC11 mouse mammary epithelial cells, which differentiate and synthesize β‐casein following growth to confluency an