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NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population

✍ Scribed by Julie Gauthier; Anna Bonnel; Judith St-Onge; Liliane Karemera; Sandra Laurent; Laurent Mottron; Éric Fombonne; Ridha Joober; Guy A. Rouleau

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 44 KB
Volume: 132B
Category: Article
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.30066

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✦ Synopsis

Abstract

Jamain [2003: Nat Genet 34:27–29] recently reported mutations in two neuroligin genes in sib‐pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X‐linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism. © 2004 Wiley‐Liss, Inc.

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