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NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway

✍ Scribed by Horng, Tiffany; Bezbradica, Jelena S; Medzhitov, Ruslan

Book ID
109923423
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
567 KB
Volume
8
Category
Article
ISSN
1529-2908

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## Abstract Interleukin‐15 (IL‐15) is a pleiotropic cytokine of the 4 α‐helix bundle family, which binds to a receptor complex that displays common elements with the IL‐2 receptor and a unique high‐affinity Ξ± chain. This review focuses on juxtacrine and reverse signaling levels in the IL‐15/IL‐15R