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NKG2D Ligands Expression and NKG2D-Mediated NK Activity in Sezary Patients

✍ Scribed by Dulphy, Nicolas; Berrou, Jeannig; Campillo, José A; Bagot, Martine; Bensussan, Armand; Toubert, Antoine

Book ID: 109875221
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 561 KB
Volume: 129
Category: Article
ISSN: 0022-202X
DOI: 10.1038/jid.2008.256

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## Abstract NKG2D operates as an activating receptor on natural killer (NK) cells and costimulates the effector function of αβ CD8^+^ T cells. Ligands of NKG2D, the MHC class I chain‐related (MIC) and UL16 binding protein (ULBP) molecules, are expressed on a variety of human tumors, including melan