✦ LIBER ✦

NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics

✍ Scribed by Kunio Matsumoto; Toshikazu Nakamura

Book ID: 108582266
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 1010 KB
Volume: 94
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2003.tb01440.x

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## Abstract NK4 exhibits two distinct biological actions: antagonistic inhibition of hepatocyte growth factor (HGF) through binding to the Met/HGF receptor, and antiangiogenic action through binding to perlecan. Here, the anti‐tumor effect of NK4 on malignant pleural mesothelioma was investigated.