NK cells from tuberculous pleurisy express high ICAM-1 levels and exert stimulatory effect on local T cells
✍ Scribed by Pablo Schierloh; Noemí Yokobori; Laura Geffner; Luciana Balboa; María M. Romero; Rosa M. Musella; Mercedes Alemán; Jorge Castagnino; Juan Basile; Silvia S. de la Barrera; Eduardo Abbate; María C. Sasiain
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 453 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Abstract
Tuberculous pleurisy, one of the most common manifestations of extrapulmonary tuberculosis, is characterized by a T‐cell‐mediated hypersensitivity reaction along with a Th1 immune profile. In this study, we investigated functional cross‐talk among T and NK cells in human tuberculous pleurisy. We found that endogenously activated pleural fluid‐derived NK cells express high ICAM‐1 levels and induce T‐cell activation ex vivo through ICAM‐1. Besides, upon in vitro stimulation with monokines and PAMP, resting peripheral blood NK cells increased ICAM‐1 expression leading to cellular activation and Th1 polarization of autologous T cells. Furthermore, these effects were abolished by anti‐ICAM‐1 Ab. Hence, NK cells may contribute to the adaptive immune response by a direct cell‐contact‐dependent mechanism in the context of Mycobacterium tuberculosis infection.