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NK cell functions restrain T cell responses during viral infections

✍ Scribed by Helen C. Su; Khuong B. Nguyen; Thais P. Salazar-Mather; Melanie C. Ruzek; Marc Y. Dalod; Christine A. Biron

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
414 KB
Volume
31
Category
Article
ISSN
0014-2980

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✦ Synopsis

NK cell functions for regulation of T cell responses were evaluated during acute viral infections. In vivo depletion studies established that the presence of NK cells in murine cytomegalovirus (MCMV)-infected immunocompetent mice negatively affected CD4 and CD8 T cell IFN-+ expression, bromodeoxyuridine (BrdU) incorporation, and expansion. To evaluate NK cell effects, under conditions when NK cells do not control viral replication, experiments were performed using lymphocytic choriomeningitis virus (LCMV). Depletion of NK cells did not affect LCMV-elicited T cell responses in immunocompetent mice; however, the presence of NK cells did inhibit CD4 T cell IFN-+ production, BrdU incorporation, and expansion in infected MHC class I-and CD8 T cell-deficient g 2M -/-mice. Together, the results reveal a previously unappreciated immunoregulatory role of NK cells for downstream T cell responses.

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