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Nitrostyrene Derivatives of Adenosine 5′-Glutarates Modified with an Alkyl Spacer and their inhibitory activity on epidermal growth factor receptor protein tyrosine kinase

✍ Scribed by Stefan Peterli; Dieter Hubmann; Urs Séquin; Helmut Mett; Peter Traxler

Publisher: John Wiley and Sons
Year: 1994
Tongue: German
Weight: 796 KB
Volume: 77
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19940770109

No coin nor oath required. For personal study only.

✦ Synopsis

From the Ph. D. thesis of Sr. P. [ 11.

From the diploma thesis of D. H . [2].

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Nitrostyrene Derivatives of Adenosine 5′

Nitrostyrene Derivatives of Adenosine 5′-Glutarates as Selective Inhibitors of the Epidermal Growth Factor Receptor Protein Tyrosine Kinase

✍ Stefan Peterli; Regina Stumpf; Marc Schweizer; Urs Séquin; Helmut Mett; Peter Tr 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 German ⚖ 751 KB

## Abstract The syntheses and biological activities of some nitrostyrene derivatives of adenosine 5′‐glutarates, a novel class of selective, bi‐substrate‐type inhibitors of the EGF receptor protein tyrosine kinase with __IC__~50~ values around 1 μM. Only marginal inhibition of the tyrosine kinases