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Nitrosoguanidine-induced adaptive repair inPseudomonas aeruginosa

✍ Scribed by Sheikh Ajaz Rasool; Aamir Mirza; Mohammad Ayub Khan

Publisher: Springer-Verlag
Year: 1990
Tongue: English
Weight: 275 KB
Volume: 17
Category: Article
ISSN: 0172-8083
DOI: 10.1007/bf00334521

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✦ Synopsis

Error-proof adaptive repair has been demonstrated in Pseudomonas aeruginosa. Cells of actively replicating wild-type Ps. aeruginosa (ATCC27853) and its auxotrophic derivative PAO 286 were subjected to stepwise adaptation (up to 1 microgram ml-1) by nitrosoguanidine (MNNG). Such cells resisted lethal and mutagenic effects of MNNG-challenge (lethal) doses more efficiently than those of nonadapted cultures. Similarly, reactivation of alkylated Pseudomonas phages was enhanced in adapted cells only. Induction of adaptive repair enzymes was sensitive to chloramphenicol (protein synthesis-inhibiting antibiotic) during adaptation treatment only. Protein extract from adapted cells showed increased levels in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE).

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