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Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease

✍ Scribed by Gu, Z; Nakamura, T; Yao, D; Shi, Z-Q; Lipton, S A


Book ID
110017011
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
84 KB
Volume
12
Category
Article
ISSN
1350-9047

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Several links exist between the two mechanisms of neuronal degeneration (i.e., oxygen radical production and mitochondrial damage) proposed to have a role in Parkinson's disease. Indeed, mitochondria are critical targets for the toxic injury induced by oxygen radicals, and experimental evidence sugg