Nitromethyleneimidazolidine Radioligand ([3H]NMI): High Affinity and Cooperative Binding for House Fly Acetylcholine Receptor

[6-chloro-3-pyridylmethyl-3H] neonicotin

[6-chloro-3-pyridylmethyl-3H] neonicotinoids as high-affinity radioligands for the nicotinic acetylcholine receptor: Preparation using NaB3H4 and LiB3H4

✍ Bachir Latli; Chit Than; Hiromi Morimoto; Philip G. Williams; John E. Casida 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 383 KB

NaB'H, and LiB'H, at 78% and 97% isotopic enrichments, respectively, were used in the synthesis of 'H-labeled 1-(6-chloro-3-pyridyl)methyl-2-nitromethyleneimidazolidine (CH-IMI) and N'-[(6-chloro-3pyridyl) methyl1 -N"-cyano-N' -methylacetamidine (acetarniprid) (two very potent insecticides) and of 1