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Nitroimidazoles. Part 4. Synthesis and anti-HIV Activity of New 5-Alkylsulfanyl and 5-(4′-Arylsulfonyl)piperazinyl-4-nitroimidazole Derivatives.

✍ Scribed by Yaseen A. Al-Soud; Najim A. Al-Masoudi; Erik De Clercq; Christoph Paneccoque

Publisher
John Wiley and Sons
Year
2007
Weight
15 KB
Volume
38
Category
Article
ISSN
0931-7597

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Nitroimidazoles, part 4: Synthesis and a
Nitroimidazoles, part 4: Synthesis and anti-HIV activity of new 5-alkylsulfanyl and 5-(4′-arylsulfonyl)piperazinyl-4-nitroimidazole derivatives
✍ Yaseen A. Al-Soud; Najim A. Al-Masoudi; Erik De Clercq; Christoph Paneccoque 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB

## Abstract The development of new HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating structures of increased potency. On this basis, a series of 5‐alkylsulfanyl and 5‐(4′‐arylsulfonyl)piperazine derivatives of 1‐phenyl‐2‐alkyl‐4‐nitroimidazoles **5–21*