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Nitroglycerin Tolerance in Vitro: Effect on cGMP Turnover in Vascular Smooth Muscle

✍ Scribed by Axelsson, Krister L. ;Karlsson, Jan-Olof G.


Book ID
114800390
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
527 KB
Volume
55
Category
Article
ISSN
0001-6683

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We have studied the effects of mefloquine on isolated rat aorta. Mefloquine (10(-8) to 1.6 x 10(-4) mol.l-1) relaxed aortic rings precontracted with both noradrenaline (10(-7) mol.l-1) and potassium chloride (60 mmol.l-1). The mefloquine-induced relaxation was somewhat attenuated by removal of the e