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Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: A preliminary report

✍ Scribed by Frank W. Lee; Jin Hu; Craig H. Metzler; Leslie Z. Benet


Book ID
112472509
Publisher
Springer
Year
1993
Tongue
English
Weight
602 KB
Volume
21
Category
Article
ISSN
1573-8744

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Pharmacokinetic studies of the nitroglyc
✍ David T.-W. Lau; Mark Gumbleton; Christoph Labisch; Leslie Z. Benet πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 393 KB πŸ‘ 1 views

1,2-and 1,3-glyceryl dinitrates (1,2-GDN and 1,3-GDN) are the primary metabolites of glyceryl trinitrate, a commonly used anti-anginal agent. The goal of this study was to examine the pharmacokinetic properties of these metabolites in rats. Sprague-Dawley rats were infused intravenously with 0.25 or