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Nitrogen bridgehead compounds. Part 88. Synthesis of 3H, 7H-[1,4]diazepino[3,4-b]quinazoline-3,7-diones

✍ Scribed by Mónika Szabó; József Kökösi; László Örfi; Attila Kovács; István Hermecz

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
371 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

3__H__,7__H__‐[1,4]Diazepino[3,4‐b]quinazolone‐3,7‐diones 9, 11 were synthesized starting from 2‐(1‐bromo‐ethyl)quinazolin‐4(3__H__)‐ones 3 and 17 via 2‐[1‐(4‐methoxyphenylamino)ethyl]quinazolin‐4(3__H__)‐ones 4 and 18. Cyclization of 3‐[2‐(1‐bromoethyl)‐4‐oxo‐3,4‐dihydroquinazolin‐3‐yl)propionic acid 14 by the action of triethylamine provided the first representative of the tricyclic 7__H__‐[1,4]oxazepino[3,4‐b]quinazoline‐3,7‐dione system, compound 15. The new tricyclic derivatives 9, 11 and 15 are characterized by uv, ir and ^1^H nmr spectroscopy.

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✍ R. L. Sharam; Jasbir Singh; Surinder Kumar; Daljeet Kour; Anand Sachar; Shallu; 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 251 KB

## Abstract magnified image Quinazoline‐2,4(1__H__,3__H__)‐dione (1) reacts with α,ω‐dihaloalkanes to generate three types of quinazolinophanes. When the number of carbon atoms in the dihaloalkanes is **9**, a mixture of all the three types of quinazolinophanes (**2**), (**3**) and (**4**) was pro