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Nitrogen Alkylation of schiff bases and amidines as a route to N-alkyl amino acids

✍ Scribed by Martin J. O'Donnell; William A. Bruder; Byron W. Daugherty; Deshan Liu; Krzysztof Wojciechowski


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
224 KB
Volume
25
Category
Article
ISSN
0040-4039

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General method for the synthesis of N-me
✍ Jason J. Chruma; Dalibor Sames; Robin Polt πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 127 KB

## N-methyl amino acids, including L-abrine, and N-alkyl amino esters, were synthesized by reductive amination of O'Donnell's Schiff base amino esters with NaBH3CN and formaldehyde, or the appropriate aldehyde in CH3CN or THF in good to excellent yields, and with high purity.