Nitrile hydratase and related non-heme iron sulfur complexes

✍ Scribed by I. Artaud; S. Chatel; A.S. Chauvin; D. Bonnet; M.A. Kopf; P. Leduc

• Book ID: 104111975
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 176 KB
• Volume: 190-192
• Category: Article
• ISSN: 0010-8545
• DOI: 10.1016/s0010-8545(99)00101-0

✦ Synopsis

Iron-containing nitrile hydratases (NHases) are characterized by a low spin Fe(III) state and a high wavelength absorption at 700 nm. The first X-ray structure reveals a new type of N 2 S 3 (O) iron coordination sphere, all the ligands being part of a small peptide, Cys X Y Cys Ser Cys, the two nitrogens arising from the amides of the peptide main chain, and the three thiolates from the cysteines. Several iron complexes with a mixed nitrogen sulfur coordination sphere have been synthesized and characterized by UV, EPR and electrochemistry, the two nitrogens arising from amide residues or bipyridine moiety. Iron(III) complexes, with deprotonated carboxamido nitrogen donors, are pentacoordinated. They are stable over a wide range of potential, have a S=3/2 spin state and exhibit a visible absorption between www.elsevier.com/locate/ccr