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Nitric Oxide Synthesis Requires Activity of the Cationic and Neutral Amino Acid Transport System y+L in Human Umbilical vein Endothelium

✍ Scribed by Yerko Arancibia-Garavilla; Fernando Toledo; Paola Casanello; Luis Sobrevia


Book ID
110109467
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
293 KB
Volume
88
Category
Article
ISSN
0958-0670

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## Abstract Elevated extracellular D‐glucose increases transforming growth factor β1 (TGF‐β1) release from human umbilical vein endothelium (HUVEC). TGF‐β1, via TGF‐β receptors I (TβRI) and TβRII, activates Smad2 and mitogen‐activated protein kinases p44 and p42 (p42/44^mapk^). We studied whether D