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Nitric oxide synthase isoform III gene expression in rat liver is up-regulated by lipopolysaccharide and lipoteichoic acid

โœ Scribed by M Bucher; K.P Ittner; M Zimmermann; K Wolf; J Hobbhahn; A Kurtz


Book ID
117107940
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
452 KB
Volume
412
Category
Article
ISSN
0014-5793

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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe