Decreased IL-12 production and Th1 cell
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Daniela Mazzeo; Paola Panina-Bordignon; Helios Recalde; Francesco Sinigaglia; Da
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Article
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1998
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John Wiley and Sons
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English
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IL-12 is a 75-kDa heterodimeric cytokine composed of two covalently linked p35 and p40 chains. This pro-inflammatory cytokine plays a prominent role in the development of Th1 cell-mediated immune responses. Th1 cell-mediated immune responses have been implicated in the pathogenesis of chronic inflam