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Nitric Oxide Produced During Sublethal Ischemia Is Crucial for the Preconditioning-Induced Down-Regulation of Glutamate Transporter GLT-1 in Neuron/Astrocyte Co-Cultures

✍ Scribed by Takeshi Yamada; Koichi Kawahara; Tatsuro Kosugi; Motoki Tanaka

Publisher: Springer
Year: 2006
Tongue: English
Weight: 506 KB
Volume: 31
Category: Article
ISSN: 0364-3190
DOI: 10.1007/s11064-005-9077-4

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## Abstract Sublethal ischemia leads to increased tolerance against subsequent prolonged cerebral ischemia in vivo. In the present study, we investigated the roles of the astrocytic glutamate (Glu) transporter GLT‐1 in preconditioning (PC)‐induced neuronal ischemic tolerance in cortical neuron/astr