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Nitric oxide modulates the angiogenic phenotype of middle-T transformed endothelial cells

✍ Scribed by Lucia Morbidelli; Sandra Donnini; Marina Ziche

Book ID
117755654
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
270 KB
Volume
33
Category
Article
ISSN
1357-2725

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S-nitroso-N-acetyl-D,L-acetylpenicillamine (SNAP), a chemical donor of NO, inhibited serum-and basic fibroblast growth factor (bFCF)-stimulated cultured endothelial cell (EC) proliferation in a dose-dependent manner. The inhibitory effect of NO was reversible after washoff of SNAP-containing media.