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Nitric oxide inhibits LPS-induced tumor necrosis factor synthesis in vitro and in vivo

✍ Scribed by Teresa Iuvone; Fulvio D'Acquisto; Rosa Carnuccio; Massimo Di Rosa


Book ID
116019277
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
376 KB
Volume
59
Category
Article
ISSN
0024-3205

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Tumor necrosis factor-alpha is a principal mediator of the pathophysiological effects of endotoxemia and endotoxin shock. Tumor necrosis factor-a also contributes to the stimulation of nitric oxide synthesis by the induction of the enzyme nitric oxide synthase in a variety of tissues. Although the i