Nitric oxide inhibition of endothelial cell mitogenesis and proliferation
โ Scribed by Rajabrata Sarkar; R. Clinton Webb; James C. Stanley
- Book ID
- 117220520
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 629 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0039-6060
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๐ SIMILAR VOLUMES
S-nitroso-N-acetyl-D,L-acetylpenicillamine (SNAP), a chemical donor of NO, inhibited serum-and basic fibroblast growth factor (bFCF)-stimulated cultured endothelial cell (EC) proliferation in a dose-dependent manner. The inhibitory effect of NO was reversible after washoff of SNAP-containing media.
The role of nitric oxide (NO) from endogenous and exogenous sources in regulating large vessel and microvascular endothelial cell proliferation was investigated. Exogenous NO liberated from five different chemical donors inhibited bovine aortic, bovine retinal microvascular, and human umbilical vein