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Nitric oxide in wound-healing

✍ Scribed by Jeff S. Isenberg; Lisa A. Ridnour; Michael Graham Espey; David A. Wink; David A. Roberts

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 169 KB
Volume: 25
Category: Article
ISSN: 0738-1085
DOI: 10.1002/micr.20168

No coin nor oath required. For personal study only.

✦ Synopsis

Modulation of the complex process of wound-healing remains a surgical challenge. Little improvement beyond controlling infection, gentle tissue handling, and debridement of necrotic tissue has been had in the modern era. However, increasing appreciation of the process from a biomolecular perspective offers the potential for making significant strides in wound modulation. The bioactive molecule nitric oxide was found to have wide-ranging impact on cellular activities, including the cellular responses engendered by wound healing. Current research suggests that nitric oxide and several nitric oxide donors can exert biologic effects, although the particular net responses of cells contributing to wound repair are context-dependent.

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