## Abstract Articular chondrocytes are known to synthesize large amounts of nitric oxide in response to exposure to interleukin‐1, but the role of this radical in proteoglycan turnover remains controversial. In this study, we used two different inhibitors of nitric oxide synthase, N^G^‐methyl‐L‐arg
Nitric oxide enhances cyclooxygenase activity in articular cartilage
✍ Scribed by L. Manfield; D. Jang; G. A. C. Murrell
- Book ID
- 105517292
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1996
- Tongue
- English
- Weight
- 563 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1420-908X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
We have evaluated the role of nitric oxide (NO) on the cyclooxygenase pathway in mouse glial cells. Exposure of primary cultures of neonatal mouse cortical astrocytes to bacterial lipopolysaccharide (LPS; 1 pg/ml, 18 h) caused an increase in the release of both nitrite (NO,) and prostaglandin E2 (PG
Transglutaminases (TGases) (E.C. 2.3.2.13) catalyze a posttranslational modification of proteins and are associated with biomineralization in growth plate cartilage. Type I1 TGase participates in the activation of latent transforming growth factor P (TGFP), a crucial factor for both normal cartilage
## Abstract Osteoarthritis (OA) is associated with increased levels of reactive oxygen species. This study investigated if increased oxidative DNA damage accumulates in OA articular cartilage compared with non‐OA articular cartilage from pigs with spontaneous OA. Additionally, the ability of nitric