Differences in the disposition and toxic
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May J. Tsai; Dr. Eminy H. Y. Lee
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Article
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1994
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John Wiley and Sons
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English
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Species difference in the susceptibility to l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) was investigated in cultured rat and mouse astrocytes, where 1-methyl-4-phenylpyridinium (MPP+), the toxic mediator of MPTP, is formed. Type A monoamine oxidase (MAO) predominated in both rat and mouse as