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Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells

✍ Scribed by Yoshihisa Kitamura; Wataru Kamoshima; Shun Shimohama; Yasuyuki Nomura; Takashi Taniguchi


Book ID
117410256
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
886 KB
Volume
32
Category
Article
ISSN
0197-0186

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## Abstract Nitric oxide (NO) is cytotoxic for human SH‐SY5Y neuroblastoma cells. While nuclear condensation was visible in cells treated with nitric oxide donors, we observed that the plasma membrane remained intact, indicating that NO induced apoptotic cell death. We analyzed the NO‐induced apopt