Nitric oxide does not promote iron release from ferritin

✍ Scribed by Jean Laulhère; Marc Fontecave

• Publisher: Springer Netherlands
• Year: 1996
• Tongue: English
• Weight: 337 KB
• Volume: 9
• Category: Article
• ISSN: 1572-8773
• DOI: 10.1007/bf00188084

✦ Synopsis

It has been previously reported that iron release from ferritin could be promoted by nitric oxide (NO) generated from sodium nitroprusside. It was thus proposed that some of the toxic effects of NO could be related to its ability to increase intracellular free iron concentrations and generate an oxidative stress. On the contrary, the iron exchange experiments reported here show that NO from S-nitrosothiols is unable to promote iron release from ferritin. The discrepancy may be explained by the disregarded ability of ferrozine, the ferrous trap used in the previous report, to mobilize iron both from ferritin and from sodium nitroprusside spontaneously.