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Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

✍ Scribed by J. Størling; J. Binzer; A. K. Andersson; R. A. Züllig; M. Tonnesen; R. Lehmann; G. A. Spinas; S. Sandler; N. Billestrup; T. Mandrup-Poulsen


Publisher
Springer
Year
2005
Tongue
English
Weight
274 KB
Volume
48
Category
Article
ISSN
0012-186X

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## Abstract Ursolic acid (UA), a pentacyclic triterpenoid compound, has been demonstrated to have an antiproliferative effect in various tumors. We investigated the cell killing effects of UA in the human hormone refractory prostate cancer cell line, PC‐3 cells. Also, the molecular mechanisms under