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Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease

✍ Scribed by Marı́a C. Carreras; Marı́a C. Franco; Jorge G. Peralta; Juan J. Poderoso

Book ID
116727845
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
292 KB
Volume
25
Category
Article
ISSN
0098-2997

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## Nitric oxide (NO) and reactive oxygen species (ROS) are important mediators in the pathogenesis of inflammatory bowel disease (IBD). NO in IBD can be either harmful or protective. NO can react with superoxide anions (O 2 • ), yielding the toxic oxidizing agent peroxynitrite (ONOO ). Peroxynitri