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Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis

✍ Scribed by Sandau, Katrin; Pfeilschifter, Josef; Brüne, Bernhard

Book ID
109884895
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
877 KB
Volume
52
Category
Article
ISSN
0085-2538

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## Abstract Jurkat T‐lymphocytes lack p53 and Bax but contain p73 and Bid and are killed by etoposide (ETO). With ETO c‐abl is phosphorylated and phosphorylated p73 increased. Translocation of full‐length Bid to mitochondria follows, with induction of the mitochondrial permeability transition (MPT)