Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells

The peroxisome proliferator-activated re

The peroxisome proliferator-activated receptor-γ agonist 1,1-bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells

✍ Ronald B. Tjalkens; Xuhong Liu; Brianne Mohl; Tyler Wright; Julie A. Moreno; Dav 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

## Abstract Reactive astrogliosis is a prominent neuropathologic feature of manganism, a neurodegenerative disorder caused by excessive accumulation of manganese (Mn) in the basal ganglia. Activation of astrocytes has been linked to neuronal injury in manganism resulting from overproduction of infl