Nitric oxide and guanosine 3′,5′-cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units

Nitric oxide donors stimulate bile flow

Nitric oxide donors stimulate bile flow and glutathione disulfide excretion independent of guanosine 3′,5′-cyclic monophosphate in the isolated perfused rat liver

✍ M Trauner; M H Nathanson; A Mennone; S A Rydberg; J L Boyer 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 296 KB

NO synthase and have the capacity to produce large amounts Nitric oxide (NO) modulates several metabolic funcof NO in response to lipopolysaccharides and inflammatory tions in hepatocytes, but the role of NO in bile secretion cytokines. [3][4][5][6] NO donors, such as sodium nitroprusside (SNP) has