Nitric acid esters of pyrimidine nucleosides

✍ Scribed by R. Duschinsky; Ursula Eppenberger

• Book ID: 104241190
• Publisher: Elsevier Science
• Year: 1967
• Tongue: French
• Weight: 324 KB
• Volume: 8
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)89925-1

✦ Synopsis

In view of the fact that sugar nitrates are a well known class of compounds(l) it is very surprising that nucleoside nitrates have never been described. While limiting ourselves to pyrimidine deoxyriboside nitrates we wish to report the first synthesis of this species. We also wish to demonstrate in an example the usefulness of these nucleosides, whose hydroxyls are blocked by nitro groups, as intermediates for transformations in the sugar moiety.

Johnson had shown (2) that 5-bromo-and 5-chlorouracil, as well as thymine,