Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus

✍ Scribed by N. Haas; D. Schadendorf; B.M. Henz; P.G. Fuchs

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 154 KB
• Volume: 147
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2002.04925.x

✦ Synopsis

We describe a patient with a 9-year history of generalized eruptive keratoacanthoma (KA) of the Grzybowski type whose multiple skin lesions showed steady progression, resulting in a sclerotic, mask-like facial expression and ectropion. Eleven tumour biopsies representing lesions of different stages and localizations (erupting and regressing KAs, biopsies from non-involved light-protected and light-exposed skin, dermatosclerosis and squamous cell carcinomas) were analysed for human papillomavirus (HPV) sequences using a polymerase chain reaction approach capable of detecting the majority of all presently known HPV genotypes. None of the biopsy specimens proved to be HPV-positive, although HPV was detected in weakly and heavily affected control specimens by the method applied. These findings suggest an HPV-independent aetiology of this rare type of multiple KA.