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Nine New Dammarane Saponins from Gynostemma pentaphyllum

โœ Scribed by Feng Yin; Yi-Nan Zhang; Zheng-Yi Yang; Li-Hong Hu

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
178 KB
Volume
3
Category
Article
ISSN
1612-1872

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โœฆ Synopsis

Abstract

Nine new dammarane saponins, 1โ€“9, were isolated from the MeOH extract of the aerial part of Gynostemma pentaphyllum, an edible plant of the Cucurbitaceae family, that grows wildly in China. Their structures were elucidated by 1Dโ€ and 2Dโ€NMR analysis, as well as by chemical degradation. Aglycons 21,24โ€cyclopentyldammarโ€25โ€ene of 6 and 7, and 21,24โ€cyclopentyldammarane of 8 and 9, were novel. Compounds 1, 4, and 8 showed moderate antitumor activities against stomach cancer cells SGCโ€7901 and liver cancer cells BELโ€7402.

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