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NikR Repressor: High-Affinity Nickel Binding to the C-Terminal Domain Regulates Binding to Operator DNA

✍ Scribed by Peter T. Chivers; Robert T. Sauer


Book ID
108486008
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
324 KB
Volume
9
Category
Article
ISSN
1074-5521

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Previous studies indicated that DNA adducts formed by a carcinogenic diol epoxide, 7r,8t-dihydroxy-9t, 10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), can increase the affinity of the transcription factor Sp1 for DNA sequences that are not normally specific binding sites. It was suggested that a