Niemann-pick disease type C could result from a genetic deficiency of cholesterol egress from the lysosomes

Decreased estradiol release from astrocy

Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C

✍ Gang Chen; Hai-Min Li; Yi-Ren Chen; Xiao-Song Gu; Shumin Duan 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

## Abstract Niemann‐Pick disease type C (NPC) is a deadly neurodegenerative disease often caused by mutation in a gene called NPC1, which results in the accumulation of unesterified cholesterol and glycosphingolipids in the endosomal–lysosomal system. Most studies on the mechanisms of neurodegenera